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governments stamp as a less harmful alternative to cigarettes a marketing coup for Philip Morris." The company's request to the FDA has caused "heated debate and worries" among health experts about "whether the new device will lower tobacco-related deaths, or if it is just substituting one harmful product for another" and "fueling such doubts is that many of Americas leading health organizations and experts remain deeply suspicious of Philip Morris," the leading U.S

This transition suggests that prolonged exposure within a three-dimensional epithelial context recapitulates mutational processes characteristic of smoking-related lung cancers, emphasizing that the tissue-level environment facilitates the emergence of canonical tobacco-associated genomic patterns

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